Reactivity of 5-HT1A receptor in adult rats after neonatal noradrenergic neurons' lesion—Implications for antidepressant-like action
J Dabrowska, P Nowak, R Brus - Brain research, 2008 - Elsevier
The aim of this study was to assess the 5-HT1A receptor reactivity after neonatal
noradrenergic neurons' lesion. DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine), 50
mg/kg, was administered 30 min after a selective serotonin reuptake inhibitor (SSRI)—
zimelidine (10 mg/kg) on the 1st and 3rd day of life. Zimelidine was used to prevent
serotonin (5-HT) depletion. 5-HT1A autoreceptor is involved in the regulation of 5-HT
release as well as the pathogenesis of depression. During a microdialysis study of …
noradrenergic neurons' lesion. DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine), 50
mg/kg, was administered 30 min after a selective serotonin reuptake inhibitor (SSRI)—
zimelidine (10 mg/kg) on the 1st and 3rd day of life. Zimelidine was used to prevent
serotonin (5-HT) depletion. 5-HT1A autoreceptor is involved in the regulation of 5-HT
release as well as the pathogenesis of depression. During a microdialysis study of …
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